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Name: Guiran Xiao

Academic Title: professor (tenure track),Ph.D

Post:

Department: School of Food Science and Engineering, Hefei University of Technology

Email: xiaoguiran.101@163.com

Tel: +86-17730227689

  

Education and Trains

2006-2010: Northeast Forestry University, Biological Sciences

2010-2015: Tsinghua University, PhD, Molecular Cell Biology

2015-present: HeFei University of Technology, Professor



Main Research Fields

Metal homeostasis and diseases in Drosophila models

The homeostasis of metals, such as zinc and iron, is not well elucidated in multicellular organisms. Many diseases may be relevant to trace metal metabolism. For example, neurodegeneration is often accompanied by metal accumulation in the affected pathological regions. In addition, several important molecules involved in neurodegeneration such as APP, Prion, have been shown to bind metals with high affinity. It is unclear, however, whether this association is functional or significant in disease development. 

The excellent genetic platform of Drosophila has not yet been well taken advantage of to address the biology of trace element metabolism. We adopt the fruit fly to study metal homeostasis and diseases.

  


Courses

Immunology, food biotechnology, Experimental principles of Biotechnology


Funds

Foundation for Advanced Talents by HFUT

National Postdoctoral Program for Innovative Talents

National Natural Science Foundation of China

the Fundamental Research Funds for the Central Universities


Publications

1.Xiao, G. and B. Zhou (2018). ZIP13: a study of Drosophila reveals insights to the human disease. Frontiers in Genetics. DOI: 10.3389/fgene.2017.00234. (SCI源刊,影响因子3.789)                   

2.Xiao, G. and B. Zhou (2016). What can flies tell us about zinc homeostasis? Arch Biochem Biophys 611: 134-141. SCI源刊,影响因子3.165

3.Liu, Z. H., J. J. Ding, et al. (2016). Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats. Sci Rep 6: 32492. SCI源刊,影响因子4.259

4.Xiao, G., Wan, Z., Fan, Q., et al. (2014). The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Elife, e03191.SCI源刊,影响因子8.56

5.Xiao, G., Fan, Q., Wang, X., and Zhou, B. (2013). Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding. Proc Natl Acad ScU S A 110, 14995-15000.SCI源刊, 影响因子9.809

6.Lang, M., Fan, Q., Wang, L., Zheng, Y., Xiao, G., Wang, X., Wang, W., Zhong, Y., and Zhou, B. (2013). Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Abeta42-induced Alzheimer's disease-like symptoms. Neurobiol Aging 34, 2604-2612. SCI源刊, 影响因子6.098

7.Lang, M., Wang, L., Fan, Q., Xiao, G., Wang, X., Zhong, Y., and Zhou, B. (2012). Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates abeta pathology in a Drosophila model of Alzheimer's disease. PLoS Genet 8, e1002683.SCI源刊,影响因子9.440


Awards and activities

National Postdoctoral Program for Innovative Talents

  


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